For Referring Veterinarians
Our goal is to simplify the referral process as much as possible so that you can continue on with your day with minimal interruption. Our specialty services have doctors on-call during the week to receive emergency cases during normal business hours and our emergency services veterinarians are available 24/7.
To refer a patient to one of our services please do the following:
We like to know how we're doing
We would love to hear about your experience with our referral process. Please take our brief survey by following this link: Referring Veterinarian Survey
To make the process even simpler, we have provided an online Referral Form so that printing and faxing are no longer required. Just fill out the form, click submit, give us a call, and we will do the rest!
Canine Brain Tumor Research Project
What is the canine brain tumor research project?
The project is a collaborative effort between Celsion Corporation and veterinarians at Veterinary Referral & Critical Care (VRCC) of Manakin-Sabot, VA evaluating a novel gene therapy (GEN-1) for the treatment of brain tumors. The goal of this project is to evaluate the safety and feasibility of intra-cranially administering GEN-1 following tumor resection surgery. The results of this study will be used to support the initiation of clinical trials aimed at treating human patients with glioblastoma multiforme. The following treatment design will be used:
- 1. Surgery to remove as much of the tumor as possible.
- 2. Subcutaneous implantation of a reservoir device with access to the resection cavity.
- 3. Repeated administration (3x) of the gene therapy (GEN-1) through the device directly into the resection cavity.
What dogs are eligible for the project?
Any dog that is approximately 10 Kg in weight or greater with an intra-axial brain tumor and that is healthy enough to undergo resection surgery can be included in this study. The specific tumor type will not be an eligibility requirement although there will be requirements regarding the location of the tumor that will inform a final eligibility decision.
How much will it cost?
All project related treatments, analytical work and follow-ups will be performed at NO COST to the dog's owners. Owners will be responsible for transportation to and from VRCC for treatments and follow-up visits.
What is the therapy?
In this study, GEN-1, a nanoparticle formulation that contains the IL-12 gene will be repeatedly delivered intra-cranially into dogs following tumor resection surgery. IL-12 protein is known to have very potent anti-tumor properties that work by stimulating the body's own immune response to help kill tumor cells. In addition, IL-12 can also help to prevent the formation of new blood vessels that are required for tumor growth. Use of GEN-1 is currently being evaluated in human clinical trials for treating ovarian cancer and has shown in animal models that it can slow and/or eliminate a wide variety of tumor types, including glioblastomas. Although this study is designed to evaluate the feasibility and safety of repeatedly administering GEN-1 into the resection cavity in the brain that has resulted from surgically removing a brain tumor, it has the potential to reduce or eradicate the remaining tumor in dogs suffering from brain cancer.
If you are, or know of a pet owner that may have an interest in participating in this research project, please contact Dr. Jeff Clarke or Dr. Anna Aman, here at VRCC.